Drug interactions
Ranolazine + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Ranolazine and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine prolongs QTc, and vilanterol as a beta-agonist can add to QT and heart rate effects. Systemic exposure from inhalation is low, so the risk is modest but relevant in patients with cardiac disease.
What this interaction means in plain words
Ranolazine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc effects and beta-adrenergic cardiovascular stimulation.
What to do
Monitor ECG and heart rhythm in patients with QT risk factors, and correct hypokalemia. Avoid exceeding recommended inhaler doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ranolazine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Ranolazine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine prolongs QTc, and vilanterol as a beta-agonist can add to QT and heart rate effects. Systemic exposure from inhalation is low, so the risk is modest but relevant in patients with cardiac disease.
How serious is the interaction between Ranolazine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rhythm in patients with QT risk factors, and correct hypokalemia. Avoid exceeding recommended inhaler doses.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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