Drug interactions
Ranolazine + Venlafaxine
Severity: Moderate
Ranolazine and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine can prolong QTc, particularly at higher doses or in overdose, and ranolazine also prolongs QTc. Combined use may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Ranolazine and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG and correct electrolyte abnormalities, using the lowest effective venlafaxine dose. Reassess therapy if QTc lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Ranolazine with Venlafaxine?
MediHelp rates the interaction as moderate. Ranolazine and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine can prolong QTc, particularly at higher doses or in overdose, and ranolazine also prolongs QTc. Combined use may increase the risk of ventricular arrhythmia.
How serious is the interaction between Ranolazine and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct electrolyte abnormalities, using the lowest effective venlafaxine dose. Reassess therapy if QTc lengthens significantly.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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