Drug interactions
Ranolazine + Vincristine liposomal
Severity: Moderate
Ranolazine and Vincristine liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is a P-gp substrate and ranolazine inhibits P-gp, so vincristine exposure could rise. This may increase neurotoxicity, although clinical data are limited.
What this interaction means in plain words
Ranolazine and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-gp inhibition by ranolazine reducing vincristine efflux and clearance.
What to do
Monitor for peripheral neuropathy, constipation and ileus. Consider an alternative to ranolazine if neurotoxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ranolazine with Vincristine liposomal?
MediHelp rates the interaction as moderate. Ranolazine and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vincristine is a P-gp substrate and ranolazine inhibits P-gp, so vincristine exposure could rise. This may increase neurotoxicity, although clinical data are limited.
How serious is the interaction between Ranolazine and Vincristine liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy, constipation and ileus. Consider an alternative to ranolazine if neurotoxicity emerges.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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