Drug interactions
Rapacuronium + Sevoflurane
Severity: Moderate
Rapacuronium and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as sevoflurane potentiate non-depolarizing neuromuscular blockers, prolonging and intensifying blockade. Rapacuronium has been withdrawn from the market in many regions because of severe bronchospasm.
What this interaction means in plain words
Rapacuronium and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sevoflurane reduces neuromuscular transmission sensitivity at the neuromuscular junction, enhancing non-depolarizing blockade.
What to do
Reduce the neuromuscular blocker dose and monitor with quantitative train-of-four. Confirm full recovery before extubation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Rapacuronium with Sevoflurane?
MediHelp rates the interaction as moderate. Rapacuronium and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as sevoflurane potentiate non-depolarizing neuromuscular blockers, prolonging and intensifying blockade. Rapacuronium has been withdrawn from the market in many regions because of severe bronchospasm.
How serious is the interaction between Rapacuronium and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the neuromuscular blocker dose and monitor with quantitative train-of-four. Confirm full recovery before extubation.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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