Drug interactions
Rasagiline + Talquetamab
Severity: Minor
Rasagiline and Talquetamab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab causes cytokine release syndrome, which can transiently suppress CYP enzymes. Rasagiline exposure may rise, especially during step-up dosing and for about two weeks after the first treatment dose.
What this interaction means in plain words
Rasagiline and Talquetamab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rasagiline belongs to Central Nervous System; Talquetamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP1A2 may reduce rasagiline clearance.
What to do
Monitor for rasagiline adverse effects such as hypotension and dyskinesia during step-up dosing and any cytokine release syndrome. Reduce the rasagiline dose if effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Rasagiline with Talquetamab?
MediHelp rates the interaction as minor. Rasagiline and Talquetamab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Talquetamab causes cytokine release syndrome, which can transiently suppress CYP enzymes. Rasagiline exposure may rise, especially during step-up dosing and for about two weeks after the first treatment dose.
How serious is the interaction between Rasagiline and Talquetamab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rasagiline adverse effects such as hypotension and dyskinesia during step-up dosing and any cytokine release syndrome. Reduce the rasagiline dose if effects emerge.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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