Drug interactions
Rasagiline + Tapentadol
Severity: Contraindicated
Rasagiline and Tapentadol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tapentadol inhibits noradrenaline reuptake and is contraindicated with MAO inhibitors, as the combination may cause hypertensive crisis or serotonin syndrome. Severe cardiovascular and CNS reactions are possible.
What this interaction means in plain words
Rasagiline and Tapentadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rasagiline belongs to Central Nervous System; Tapentadol belongs to Musculoskeletal.
Why it happens
MAO inhibition combined with tapentadol's noradrenaline reuptake inhibition, with possible serotonergic effects.
What to do
Do not use during or within 14 days of rasagiline. Select an alternative analgesic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Rasagiline with Tapentadol?
MediHelp rates the interaction as contraindicated. Rasagiline and Tapentadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tapentadol inhibits noradrenaline reuptake and is contraindicated with MAO inhibitors, as the combination may cause hypertensive crisis or serotonin syndrome. Severe cardiovascular and CNS reactions are possible.
How serious is the interaction between Rasagiline and Tapentadol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use during or within 14 days of rasagiline. Select an alternative analgesic.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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