Drug interactions
Rasagiline + Zolmitriptan
Severity: Moderate
Rasagiline and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zolmitriptan and its active metabolite are cleared in part by MAO-A, and both drugs are serotonergic. Exposure may rise, though rasagiline is MAO-B selective at usual doses.
What this interaction means in plain words
Rasagiline and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rasagiline belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects and possible reduced zolmitriptan metabolism through MAO inhibition.
What to do
Limit zolmitriptan to the lowest effective dose and monitor for serotonin toxicity. Choose another agent if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Rasagiline with Zolmitriptan?
MediHelp rates the interaction as moderate. Rasagiline and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zolmitriptan and its active metabolite are cleared in part by MAO-A, and both drugs are serotonergic. Exposure may rise, though rasagiline is MAO-B selective at usual doses.
How serious is the interaction between Rasagiline and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit zolmitriptan to the lowest effective dose and monitor for serotonin toxicity. Choose another agent if symptoms arise.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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