Drug interactions
Regorafenib + Riociguat
Severity: Moderate
Regorafenib and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP and increase riociguat exposure. Higher riociguat levels can cause symptomatic hypotension.
What this interaction means in plain words
Regorafenib and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Regorafenib belongs to Oncology; Riociguat belongs to Cardiovascular.
Why it happens
Regorafenib inhibits BCRP-mediated efflux of riociguat.
What to do
Monitor blood pressure and consider a lower riociguat dose if hypotension occurs. Regorafenib itself can cause hypertension, so reassess BP trends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Regorafenib with Riociguat?
MediHelp rates the interaction as moderate. Regorafenib and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may inhibit BCRP and increase riociguat exposure. Higher riociguat levels can cause symptomatic hypotension.
How serious is the interaction between Regorafenib and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and consider a lower riociguat dose if hypotension occurs. Regorafenib itself can cause hypertension, so reassess BP trends.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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