Drug interactions
Regorafenib + Selexipag
Severity: Moderate
Regorafenib and Selexipag: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP and thereby increase exposure to selexipag. This could enhance prostacyclin-related effects such as headache, flushing, diarrhea and hypotension.
What this interaction means in plain words
Regorafenib and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Regorafenib belongs to Oncology; Selexipag belongs to Cardiovascular.
Why it happens
Regorafenib inhibits BCRP-mediated efflux of selexipag.
What to do
Monitor for selexipag adverse effects and blood pressure, and adjust the selexipag dose if poorly tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Regorafenib with Selexipag?
MediHelp rates the interaction as moderate. Regorafenib and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may inhibit BCRP and thereby increase exposure to selexipag. This could enhance prostacyclin-related effects such as headache, flushing, diarrhea and hypotension.
How serious is the interaction between Regorafenib and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for selexipag adverse effects and blood pressure, and adjust the selexipag dose if poorly tolerated.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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