Drug interactions
Regorafenib + Topotecan
Severity: Moderate
Regorafenib and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib inhibits BCRP in vitro, and topotecan is a BCRP substrate, so exposure to topotecan may rise. This could increase myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Regorafenib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Regorafenib belongs to Oncology; Topotecan belongs to Oncology.
Why it happens
Inhibition of BCRP (ABCG2) efflux by regorafenib reduces topotecan intestinal and biliary elimination.
What to do
Monitor blood counts closely and consider topotecan dose reduction if neutropenia or diarrhea is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Regorafenib
Frequently asked questions
Can I take Regorafenib with Topotecan?
MediHelp rates the interaction as moderate. Regorafenib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib inhibits BCRP in vitro, and topotecan is a BCRP substrate, so exposure to topotecan may rise. This could increase myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Regorafenib and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and consider topotecan dose reduction if neutropenia or diarrhea is excessive.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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