Drug interactions
Regorafenib + Voxelotor
Severity: Moderate
Regorafenib and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and can increase exposure to sensitive substrates. It may raise regorafenib parent concentrations and increase adverse effects such as hepatotoxicity, though the effect has not been studied.
What this interaction means in plain words
Regorafenib and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Regorafenib belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
CYP3A4 inhibition by voxelotor decreases regorafenib clearance.
What to do
Monitor liver function and blood pressure if the combination is needed. Reduce regorafenib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Regorafenib with Voxelotor?
MediHelp rates the interaction as moderate. Regorafenib and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and can increase exposure to sensitive substrates. It may raise regorafenib parent concentrations and increase adverse effects such as hepatotoxicity, though the effect has not been studied.
How serious is the interaction between Regorafenib and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function and blood pressure if the combination is needed. Reduce regorafenib dose if toxicity occurs.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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