Drug interactions
Regorafenib + Warfarin
Severity: Moderate
Regorafenib and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib is a multi-kinase inhibitor associated with hemorrhage, and INR elevations have been reported with warfarin. The combination raises bleeding risk.
What this interaction means in plain words
Regorafenib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Regorafenib belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Additive bleeding risk from VEGFR inhibition plus vitamin K antagonism; possible CYP2C9 inhibition.
What to do
Monitor INR more often during regorafenib therapy and watch for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Regorafenib
Frequently asked questions
Can I take Regorafenib with Warfarin?
MediHelp rates the interaction as moderate. Regorafenib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib is a multi-kinase inhibitor associated with hemorrhage, and INR elevations have been reported with warfarin. The combination raises bleeding risk.
How serious is the interaction between Regorafenib and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more often during regorafenib therapy and watch for bleeding.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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