Drug interactions
Remifentanil + Stiripentol
Severity: Moderate
Remifentanil and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol frequently causes somnolence, and remifentanil is a potent opioid. Concurrent use can increase sedation and respiratory depression.
What this interaction means in plain words
Remifentanil and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Remifentanil belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABAergic enhancement by stiripentol and mu-opioid receptor agonism.
What to do
Monitor sedation and respiratory rate and start remifentanil at the lower end of the dose range. Reduce doses if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Remifentanil with Stiripentol?
MediHelp rates the interaction as moderate. Remifentanil and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol frequently causes somnolence, and remifentanil is a potent opioid. Concurrent use can increase sedation and respiratory depression.
How serious is the interaction between Remifentanil and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate and start remifentanil at the lower end of the dose range. Reduce doses if oversedation occurs.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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