Drug interactions
Remifentanil + Vortioxetine
Severity: Moderate
Remifentanil and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine has multimodal serotonergic activity and combined with opioids may contribute to serotonin syndrome. Data for remifentanil are sparse, but vigilance is warranted.
What this interaction means in plain words
Remifentanil and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Remifentanil belongs to Musculoskeletal; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from serotonin reuptake inhibition and receptor modulation plus opioid activity.
What to do
Monitor for signs of serotonin toxicity after starting or changing doses. Discontinue the serotonergic drugs and provide supportive care if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Remifentanil with Vortioxetine?
MediHelp rates the interaction as moderate. Remifentanil and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine has multimodal serotonergic activity and combined with opioids may contribute to serotonin syndrome. Data for remifentanil are sparse, but vigilance is warranted.
How serious is the interaction between Remifentanil and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity after starting or changing doses. Discontinue the serotonergic drugs and provide supportive care if it develops.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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