Drug interactions
Remimazolam + Trazodone
Severity: Moderate
Remimazolam and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, and combined use can deepen sedation and cause respiratory depression, hypotension and delayed recovery.
What this interaction means in plain words
Remimazolam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Remimazolam belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A modulation and sedating effects of trazodone.
What to do
Titrate remimazolam carefully, with continuous monitoring of oxygen saturation, respiration and blood pressure during and after the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Remimazolam
Frequently asked questions
Can I take Remimazolam with Trazodone?
MediHelp rates the interaction as moderate. Remimazolam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, and combined use can deepen sedation and cause respiratory depression, hypotension and delayed recovery.
How serious is the interaction between Remimazolam and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully, with continuous monitoring of oxygen saturation, respiration and blood pressure during and after the procedure.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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