Drug interactions
Remimazolam + Vortioxetine
Severity: Moderate
Remimazolam and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam is a short-acting benzodiazepine sedative that causes dose-related sedation and respiratory depression. Concomitant CNS-active drugs may enhance these effects, though vortioxetine contributes little sedation itself.
What this interaction means in plain words
Remimazolam and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Remimazolam belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and serotonergic CNS effects.
What to do
Titrate remimazolam carefully and monitor continuously oxygenation, respiration and vital signs during sedation and recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Remimazolam and Vortioxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Remimazolam
Frequently asked questions
Can I take Remimazolam with Vortioxetine?
MediHelp rates the interaction as moderate. Remimazolam and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Remimazolam is a short-acting benzodiazepine sedative that causes dose-related sedation and respiratory depression. Concomitant CNS-active drugs may enhance these effects, though vortioxetine contributes little sedation itself.
How serious is the interaction between Remimazolam and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully and monitor continuously oxygenation, respiration and vital signs during sedation and recovery.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
