Drug interactions
Repaglinide + Rifapentine
Severity: Moderate
Repaglinide and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is an inducer of CYP3A4 and CYP2C8 and may markedly lower repaglinide exposure. This can cause hyperglycemia and loss of diabetes control.
What this interaction means in plain words
Repaglinide and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP3A4 and CYP2C8, increasing repaglinide metabolism.
What to do
Monitor blood glucose frequently and increase the repaglinide dose as needed. Reduce the dose and monitor for hypoglycemia after rifapentine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Repaglinide with Rifapentine?
MediHelp rates the interaction as moderate. Repaglinide and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine is an inducer of CYP3A4 and CYP2C8 and may markedly lower repaglinide exposure. This can cause hyperglycemia and loss of diabetes control.
How serious is the interaction between Repaglinide and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and increase the repaglinide dose as needed. Reduce the dose and monitor for hypoglycemia after rifapentine is stopped.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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