Drug interactions
Repaglinide + Ritonavir
Severity: Moderate
Repaglinide and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is a strong CYP3A4 inhibitor and may increase repaglinide concentrations, raising the risk of hypoglycemia. Ritonavir can also affect glucose metabolism on its own.
What this interaction means in plain words
Repaglinide and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits CYP3A4, decreasing repaglinide metabolism.
What to do
Monitor blood glucose closely and consider lowering the repaglinide dose. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Repaglinide with Ritonavir?
MediHelp rates the interaction as moderate. Repaglinide and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir is a strong CYP3A4 inhibitor and may increase repaglinide concentrations, raising the risk of hypoglycemia. Ritonavir can also affect glucose metabolism on its own.
How serious is the interaction between Repaglinide and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider lowering the repaglinide dose. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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