Drug interactions
Repaglinide + Secobarbital
Severity: Moderate
Repaglinide and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital can reduce repaglinide concentrations through enzyme induction, which may weaken glycemic control. The effect is expected to be gradual and to persist for a time after the barbiturate is stopped.
What this interaction means in plain words
Repaglinide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP3A4 (and CYP2C8) increases repaglinide metabolism.
What to do
Monitor blood glucose when starting or stopping secobarbital and raise the repaglinide dose if needed. Reduce the dose again if the barbiturate is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Secobarbital?
MediHelp rates the interaction as moderate. Repaglinide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital can reduce repaglinide concentrations through enzyme induction, which may weaken glycemic control. The effect is expected to be gradual and to persist for a time after the barbiturate is stopped.
How serious is the interaction between Repaglinide and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping secobarbital and raise the repaglinide dose if needed. Reduce the dose again if the barbiturate is withdrawn.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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