Drug interactions
Repaglinide + Semaglutide
Severity: Moderate
Repaglinide and Semaglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Semaglutide used with repaglinide increases the risk of hypoglycemia. The insulin secretagogue effect is amplified by the GLP-1 agonist.
What this interaction means in plain words
Repaglinide and Semaglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Semaglutide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect of GLP-1 receptor agonism and meglitinide-stimulated insulin secretion.
What to do
Consider reducing the repaglinide dose when starting semaglutide. Monitor blood glucose and educate the patient on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Repaglinide and Semaglutide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Semaglutide
Frequently asked questions
Can I take Repaglinide with Semaglutide?
MediHelp rates the interaction as moderate. Repaglinide and Semaglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Semaglutide used with repaglinide increases the risk of hypoglycemia. The insulin secretagogue effect is amplified by the GLP-1 agonist.
How serious is the interaction between Repaglinide and Semaglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the repaglinide dose when starting semaglutide. Monitor blood glucose and educate the patient on hypoglycemia.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
