Drug interactions
Repaglinide + Vonoprazan
Severity: Minor
Repaglinide and Vonoprazan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan is a weak CYP3A4 inhibitor and may slightly raise repaglinide exposure. The clinical effect is likely small but hypoglycemia is possible.
What this interaction means in plain words
Repaglinide and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Repaglinide belongs to Endocrine; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Weak inhibition of CYP3A4 reduces repaglinide metabolism.
What to do
Monitor blood glucose when starting vonoprazan. Reduce the repaglinide dose only if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Repaglinide with Vonoprazan?
MediHelp rates the interaction as minor. Repaglinide and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vonoprazan is a weak CYP3A4 inhibitor and may slightly raise repaglinide exposure. The clinical effect is likely small but hypoglycemia is possible.
How serious is the interaction between Repaglinide and Vonoprazan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting vonoprazan. Reduce the repaglinide dose only if hypoglycemia occurs.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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