Drug interactions
Repaglinide + Voxelotor
Severity: Moderate
Repaglinide and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor may increase exposure to CYP3A4 substrates, including repaglinide. This may enhance glucose-lowering and the risk of hypoglycemia.
What this interaction means in plain words
Repaglinide and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4 and reduces repaglinide's intestinal and hepatic metabolism.
What to do
Monitor blood glucose during co-use and reduce the repaglinide dose if hypoglycemia occurs. Re-check glucose after voxelotor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Repaglinide with Voxelotor?
MediHelp rates the interaction as moderate. Repaglinide and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor may increase exposure to CYP3A4 substrates, including repaglinide. This may enhance glucose-lowering and the risk of hypoglycemia.
How serious is the interaction between Repaglinide and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during co-use and reduce the repaglinide dose if hypoglycemia occurs. Re-check glucose after voxelotor is stopped.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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