Drug interactions
Repaglinide + Zafirlukast
Severity: Moderate
Repaglinide and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is cleared by CYP2C8 and CYP3A4, and zafirlukast may increase its exposure through CYP3A4 inhibition. This raises the risk of hypoglycemia.
What this interaction means in plain words
Repaglinide and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Zafirlukast belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated repaglinide metabolism by zafirlukast.
What to do
Monitor blood glucose closely when zafirlukast is started or stopped. Reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Zafirlukast?
MediHelp rates the interaction as moderate. Repaglinide and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repaglinide is cleared by CYP2C8 and CYP3A4, and zafirlukast may increase its exposure through CYP3A4 inhibition. This raises the risk of hypoglycemia.
How serious is the interaction between Repaglinide and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when zafirlukast is started or stopped. Reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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