Drug interactions
Revefenacin + Tolterodine
Severity: Moderate
Revefenacin and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Revefenacin is an inhaled antimuscarinic with low systemic exposure, but combined with oral tolterodine anticholinergic effects may add up. Urinary retention, dry mouth, constipation and narrow-angle glaucoma may worsen.
What this interaction means in plain words
Revefenacin and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Revefenacin belongs to Respiratory; Tolterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for urinary retention, constipation and visual symptoms, and reduce or stop one drug if anticholinergic effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Revefenacin
- Cyclosporin + Revefenacin Major
- Indacaterol-glycopyrronium + Revefenacin Major
- Revefenacin + Rifampicin Major
- Revefenacin + Tiotropium Major
- Atropine + Revefenacin Moderate
- Benztropine + Revefenacin Moderate
Frequently asked questions
Can I take Revefenacin with Tolterodine?
MediHelp rates the interaction as moderate. Revefenacin and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Revefenacin is an inhaled antimuscarinic with low systemic exposure, but combined with oral tolterodine anticholinergic effects may add up. Urinary retention, dry mouth, constipation and narrow-angle glaucoma may worsen.
How serious is the interaction between Revefenacin and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and visual symptoms, and reduce or stop one drug if anticholinergic effects emerge.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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