Drug interactions
Revefenacin + Trospium
Severity: Moderate
Revefenacin and Trospium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinics, so their combination may produce additive anticholinergic effects such as dry mouth, constipation and urinary retention. Inhaled revefenacin has low systemic exposure but the effects can still add up.
What this interaction means in plain words
Revefenacin and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Revefenacin belongs to Respiratory; Trospium belongs to Genitourinary.
Why it happens
Additive antimuscarinic receptor blockade.
What to do
Monitor for urinary retention, constipation and worsening narrow-angle glaucoma symptoms, and consider a non-antimuscarinic alternative if effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trospium
- Clozapine + Trospium Major
- Pramlintide + Trospium Major
- Thioridazine + Trospium Major
- Trihexyphenidyl + Trospium Major
- Aclidinium + Trospium Moderate
- Amantadine + Trospium Moderate
Other interactions of Revefenacin
- Cyclosporin + Revefenacin Major
- Indacaterol-glycopyrronium + Revefenacin Major
- Revefenacin + Rifampicin Major
- Revefenacin + Tiotropium Major
- Atropine + Revefenacin Moderate
- Benztropine + Revefenacin Moderate
Frequently asked questions
Can I take Revefenacin with Trospium?
MediHelp rates the interaction as moderate. Revefenacin and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinics, so their combination may produce additive anticholinergic effects such as dry mouth, constipation and urinary retention. Inhaled revefenacin has low systemic exposure but the effects can still add up.
How serious is the interaction between Revefenacin and Trospium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and worsening narrow-angle glaucoma symptoms, and consider a non-antimuscarinic alternative if effects arise.
What other medicines interact with Trospium?
MediHelp also lists interactions of Trospium with, for example, Clozapine, Pramlintide, Thioridazine. The full list is on the Trospium page.
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