Drug interactions
Ribociclib + Rifabutin
Severity: Major
Ribociclib and Rifabutin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and can lower ribociclib concentrations, risking reduced efficacy. Ribociclib may also raise rifabutin levels, increasing the risk of neutropenia and uveitis.
What this interaction means in plain words
Ribociclib and Rifabutin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ribociclib belongs to Oncology; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induces CYP3A4 (less than rifampin) while ribociclib inhibits CYP3A4, which contributes to rifabutin metabolism.
What to do
Avoid if possible and choose an alternative antimycobacterial. If it must be used, monitor blood counts and ocular symptoms and assess response to ribociclib.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Ribociclib with Rifabutin?
MediHelp rates the interaction as major. Ribociclib and Rifabutin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifabutin induces CYP3A4 and can lower ribociclib concentrations, risking reduced efficacy. Ribociclib may also raise rifabutin levels, increasing the risk of neutropenia and uveitis.
How serious is the interaction between Ribociclib and Rifabutin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose an alternative antimycobacterial. If it must be used, monitor blood counts and ocular symptoms and assess response to ribociclib.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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