Drug interactions
Ribociclib + Salmeterol
Severity: Moderate
Ribociclib and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate-to-strong CYP3A4 inhibitor and can raise salmeterol exposure, which increases beta2-mediated effects such as tachycardia, tremor and hypokalemia. Ribociclib also prolongs the QT interval, and higher salmeterol levels may add to this cardiac risk.
What this interaction means in plain words
Ribociclib and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Salmeterol belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated salmeterol metabolism, with additive QT-prolonging potential.
What to do
Monitor ECG, heart rate and serum potassium, and watch for beta2-agonist adverse effects. Avoid salmeterol doses above those recommended.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Salmeterol?
MediHelp rates the interaction as moderate. Ribociclib and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate-to-strong CYP3A4 inhibitor and can raise salmeterol exposure, which increases beta2-mediated effects such as tachycardia, tremor and hypokalemia. Ribociclib also prolongs the QT interval, and higher salmeterol levels may add to this cardiac risk.
How serious is the interaction between Ribociclib and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and serum potassium, and watch for beta2-agonist adverse effects. Avoid salmeterol doses above those recommended.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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