Drug interactions
Ribociclib + Sofosbuvir-velpatasvir
Severity: Minor
Ribociclib and Sofosbuvir-velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor, and velpatasvir is partly metabolised by CYP3A4 along with CYP2B6 and CYP2C8. Exposure to velpatasvir may rise slightly, but its wide safety margin makes this unlikely to matter clinically.
What this interaction means in plain words
Ribociclib and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ribociclib belongs to Oncology; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Ribociclib inhibits CYP3A4, which contributes to velpatasvir metabolism.
What to do
No dose adjustment is needed; monitor routinely for adverse effects of the hepatitis C regimen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as minor. Ribociclib and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib is a moderate CYP3A4 inhibitor, and velpatasvir is partly metabolised by CYP3A4 along with CYP2B6 and CYP2C8. Exposure to velpatasvir may rise slightly, but its wide safety margin makes this unlikely to matter clinically.
How serious is the interaction between Ribociclib and Sofosbuvir-velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor routinely for adverse effects of the hepatitis C regimen.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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