Drug interactions
Ribociclib + Sorafenib
Severity: Major
Ribociclib and Sorafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so the combination raises the risk of arrhythmia. Ribociclib inhibits CYP3A4, and this may modestly increase exposure to sorafenib, although sorafenib is also cleared through UGT1A9.
What this interaction means in plain words
Ribociclib and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ribociclib belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Additive QT prolongation, with possible ribociclib CYP3A4 inhibition affecting sorafenib clearance.
What to do
Avoid the combination if possible. If it is needed, monitor ECG and electrolytes and watch for sorafenib toxicity such as hand-foot reaction and hypertension.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sorafenib
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Sorafenib?
MediHelp rates the interaction as major. Ribociclib and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so the combination raises the risk of arrhythmia. Ribociclib inhibits CYP3A4, and this may modestly increase exposure to sorafenib, although sorafenib is also cleared through UGT1A9.
How serious is the interaction between Ribociclib and Sorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is needed, monitor ECG and electrolytes and watch for sorafenib toxicity such as hand-foot reaction and hypertension.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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