Drug interactions
Ribociclib + Suvorexant
Severity: Moderate
Ribociclib and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant is metabolized mainly by CYP3A4, and its labeling recommends a lower dose with moderate CYP3A inhibitors. Ribociclib may raise suvorexant levels and increase next-day somnolence and impaired driving.
What this interaction means in plain words
Ribociclib and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Suvorexant belongs to Central Nervous System.
Why it happens
Ribociclib inhibits CYP3A4, reducing suvorexant clearance.
What to do
Start with a lower suvorexant dose, in line with labeling for moderate CYP3A inhibitors, and counsel on daytime drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Ribociclib with Suvorexant?
MediHelp rates the interaction as moderate. Ribociclib and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Suvorexant is metabolized mainly by CYP3A4, and its labeling recommends a lower dose with moderate CYP3A inhibitors. Ribociclib may raise suvorexant levels and increase next-day somnolence and impaired driving.
How serious is the interaction between Ribociclib and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower suvorexant dose, in line with labeling for moderate CYP3A inhibitors, and counsel on daytime drowsiness.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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