Drug interactions
Ribociclib + Tolterodine
Severity: Major
Ribociclib and Tolterodine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may increase tolterodine exposure. Both drugs can prolong the QT interval, so the combined effect on cardiac repolarization is a concern.
What this interaction means in plain words
Ribociclib and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ribociclib belongs to Oncology; Tolterodine belongs to Genitourinary.
Why it happens
CYP3A4 inhibition by ribociclib raises tolterodine levels, with additive QT prolongation.
What to do
Avoid if possible; otherwise limit tolterodine to 2 mg daily and monitor the ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolterodine
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Tolterodine?
MediHelp rates the interaction as major. Ribociclib and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib inhibits CYP3A4 and may increase tolterodine exposure. Both drugs can prolong the QT interval, so the combined effect on cardiac repolarization is a concern.
How serious is the interaction between Ribociclib and Tolterodine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise limit tolterodine to 2 mg daily and monitor the ECG and electrolytes.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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