Drug interactions
Ribociclib + Trastuzumab
Severity: Moderate
Ribociclib and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib frequently causes neutropenia, and trastuzumab can add to neutropenia when combined with myelosuppressive therapy. Trastuzumab also carries cardiac toxicity risk, while ribociclib may prolong the QT interval.
What this interaction means in plain words
Ribociclib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppression and potential additive cardiac effects; no pharmacokinetic interaction is expected.
What to do
Monitor complete blood counts and signs of infection, and follow ribociclib dose-interruption rules. Monitor ECG and cardiac function per labeling for both drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Ribociclib with Trastuzumab?
MediHelp rates the interaction as moderate. Ribociclib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib frequently causes neutropenia, and trastuzumab can add to neutropenia when combined with myelosuppressive therapy. Trastuzumab also carries cardiac toxicity risk, while ribociclib may prolong the QT interval.
How serious is the interaction between Ribociclib and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and signs of infection, and follow ribociclib dose-interruption rules. Monitor ECG and cardiac function per labeling for both drugs.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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