Drug interactions
Ribociclib + Vandetanib
Severity: Contraindicated
Ribociclib and Vandetanib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and ribociclib may also raise vandetanib levels through CYP3A4 inhibition. Together this raises the risk of torsades de pointes and sudden death.
What this interaction means in plain words
Ribociclib and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ribociclib belongs to Oncology; Vandetanib belongs to Oncology.
Why it happens
Additive QT prolongation, with possible increased vandetanib exposure from CYP3A4 inhibition by ribociclib.
What to do
Avoid the combination; use an alternative that does not prolong QT. Vandetanib labeling warns against combining it with other QT-prolonging drugs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Ribociclib with Vandetanib?
MediHelp rates the interaction as contraindicated. Ribociclib and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and ribociclib may also raise vandetanib levels through CYP3A4 inhibition. Together this raises the risk of torsades de pointes and sudden death.
How serious is the interaction between Ribociclib and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative that does not prolong QT. Vandetanib labeling warns against combining it with other QT-prolonging drugs.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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