Drug interactions
Ribociclib + Vincristine
Severity: Major
Ribociclib and Vincristine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may raise vincristine levels, increasing the risk of neurotoxicity and constipation or ileus. Vincristine is not a meaningful inhibitor of ribociclib metabolism, so the main concern is the effect on vincristine.
What this interaction means in plain words
Ribociclib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ribociclib belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4 and P-gp, reducing vincristine clearance.
What to do
Monitor closely for peripheral neuropathy, constipation and myelosuppression, and consider vincristine dose reduction or an alternative CDK4/6 inhibitor strategy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Vincristine?
MediHelp rates the interaction as major. Ribociclib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib inhibits CYP3A4 and may raise vincristine levels, increasing the risk of neurotoxicity and constipation or ileus. Vincristine is not a meaningful inhibitor of ribociclib metabolism, so the main concern is the effect on vincristine.
How serious is the interaction between Ribociclib and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for peripheral neuropathy, constipation and myelosuppression, and consider vincristine dose reduction or an alternative CDK4/6 inhibitor strategy.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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