Drug interactions
Ribociclib + Vinorelbine
Severity: Moderate
Ribociclib and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may increase vinorelbine concentrations. Both drugs cause neutropenia, so the combination can worsen myelosuppression and neurotoxicity.
What this interaction means in plain words
Ribociclib and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
CYP3A4 inhibition by ribociclib reduces vinorelbine clearance, with additive neutropenia.
What to do
Monitor blood counts and neuropathy frequently and reduce the vinorelbine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Vinorelbine?
MediHelp rates the interaction as moderate. Ribociclib and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4 and may increase vinorelbine concentrations. Both drugs cause neutropenia, so the combination can worsen myelosuppression and neurotoxicity.
How serious is the interaction between Ribociclib and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy frequently and reduce the vinorelbine dose if toxicity appears.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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