Drug interactions
Rifabutin + Rimegepant
Severity: Moderate
Rifabutin and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and can reduce rimegepant exposure, possibly causing loss of migraine efficacy. The induction effect is weaker than that of rifampicin but still relevant.
What this interaction means in plain words
Rifabutin and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifabutin belongs to Anti Bacterial; Rimegepant belongs to Central Nervous System.
Why it happens
CYP3A4 induction by rifabutin accelerates the metabolism of rimegepant.
What to do
Avoid concurrent use as labeling advises for moderate CYP3A4 inducers; use an alternative acute migraine therapy or monitor efficacy closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Rifabutin with Rimegepant?
MediHelp rates the interaction as moderate. Rifabutin and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and can reduce rimegepant exposure, possibly causing loss of migraine efficacy. The induction effect is weaker than that of rifampicin but still relevant.
How serious is the interaction between Rifabutin and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use as labeling advises for moderate CYP3A4 inducers; use an alternative acute migraine therapy or monitor efficacy closely.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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