Drug interactions
Rifabutin + Tipranavir
Severity: Major
Rifabutin and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir boosted with ritonavir greatly increases rifabutin and its active metabolite exposure. This raises the risk of rifabutin toxicity such as uveitis and neutropenia.
What this interaction means in plain words
Rifabutin and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rifabutin belongs to Anti Bacterial; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4, reducing rifabutin clearance.
What to do
Reduce the rifabutin dose by at least 75% of the usual dose. Monitor for neutropenia, uveitis and other rifabutin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rifabutin and Tipranavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Rifabutin with Tipranavir?
MediHelp rates the interaction as major. Rifabutin and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir boosted with ritonavir greatly increases rifabutin and its active metabolite exposure. This raises the risk of rifabutin toxicity such as uveitis and neutropenia.
How serious is the interaction between Rifabutin and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the rifabutin dose by at least 75% of the usual dose. Monitor for neutropenia, uveitis and other rifabutin toxicity.
What other medicines interact with Tipranavir?
MediHelp also lists interactions of Tipranavir with, for example, Alfuzosin, Amiodarone, Atorvastatin. The full list is on the Tipranavir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
