Drug interactions
Rifampicin + Selexipag
Severity: Moderate
Rifampicin and Selexipag: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin reduces exposure to the active metabolite of selexipag, which may lessen its benefit in pulmonary arterial hypertension.
What this interaction means in plain words
Rifampicin and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifampicin belongs to Anti Bacterial; Selexipag belongs to Cardiovascular.
Why it happens
Rifampicin induces CYP2C8 and other enzymes, increasing clearance of selexipag's active metabolite.
What to do
Increase the selexipag dose as tolerated, up to twice the dose, and monitor clinical response. Reduce the dose back when rifampicin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Rifampicin with Selexipag?
MediHelp rates the interaction as moderate. Rifampicin and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin reduces exposure to the active metabolite of selexipag, which may lessen its benefit in pulmonary arterial hypertension.
How serious is the interaction between Rifampicin and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase the selexipag dose as tolerated, up to twice the dose, and monitor clinical response. Reduce the dose back when rifampicin is stopped.
What other medicines interact with Selexipag?
MediHelp also lists interactions of Selexipag with, for example, Gemfibrozil, Abiraterone, Apalutamide. The full list is on the Selexipag page.
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