Drug interactions
Rifampicin + Tivozanib
Severity: Moderate
Rifampicin and Tivozanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin, a strong CYP3A4 inducer, speeds up the metabolism of tivozanib and shortens its half-life and lowers its exposure. This may reduce antitumor efficacy.
What this interaction means in plain words
Rifampicin and Tivozanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifampicin belongs to Anti Bacterial; Tivozanib belongs to Oncology.
Why it happens
Induction of CYP3A4-mediated metabolism of tivozanib by rifampicin.
What to do
Where possible, choose an alternative to rifampicin that does not induce CYP3A4. If it cannot be avoided, monitor the tumour response closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tivozanib
- Amobarbital + Tivozanib Major
- Carbamazepine + Tivozanib Major
- Phenytoin + Tivozanib Major
- Secobarbital + Tivozanib Major
- Apalutamide + Tivozanib Moderate
- Bosentan + Tivozanib Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Rifampicin with Tivozanib?
MediHelp rates the interaction as moderate. Rifampicin and Tivozanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin, a strong CYP3A4 inducer, speeds up the metabolism of tivozanib and shortens its half-life and lowers its exposure. This may reduce antitumor efficacy.
How serious is the interaction between Rifampicin and Tivozanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, choose an alternative to rifampicin that does not induce CYP3A4. If it cannot be avoided, monitor the tumour response closely.
What other medicines interact with Tivozanib?
MediHelp also lists interactions of Tivozanib with, for example, Amobarbital, Carbamazepine, Phenytoin. The full list is on the Tivozanib page.
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