Drug interactions
Rifampicin + Treprostinil
Severity: Moderate
Rifampicin and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin lowers treprostinil exposure, which may reduce control of pulmonary arterial hypertension symptoms.
What this interaction means in plain words
Rifampicin and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifampicin belongs to Anti Bacterial; Treprostinil belongs to Cardiovascular.
Why it happens
Rifampicin induces CYP2C8, increasing treprostinil metabolism.
What to do
Monitor clinical response and increase the treprostinil dose if needed. Reassess the dose after rifampicin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Treprostinil
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Rifampicin with Treprostinil?
MediHelp rates the interaction as moderate. Rifampicin and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin lowers treprostinil exposure, which may reduce control of pulmonary arterial hypertension symptoms.
How serious is the interaction between Rifampicin and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the treprostinil dose if needed. Reassess the dose after rifampicin is stopped.
What other medicines interact with Treprostinil?
MediHelp also lists interactions of Treprostinil with, for example, Aldesleukin, Alfuzosin, Amlodipine-atorvastatin. The full list is on the Treprostinil page.
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