Drug interactions
Rifampin + Risperidone
Severity: Major
Rifampin and Risperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin strongly induces CYP3A4 and P-glycoprotein and can substantially lower concentrations of risperidone and its active metabolite. This may lead to loss of antipsychotic effect and relapse.
What this interaction means in plain words
Rifampin and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Induction of CYP3A4 and P-glycoprotein by rifampin increases risperidone clearance.
What to do
Monitor for loss of psychiatric control and consider increasing the risperidone dose. Reduce the dose again after rifampin is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Rifampin with Risperidone?
MediHelp rates the interaction as major. Rifampin and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampin strongly induces CYP3A4 and P-glycoprotein and can substantially lower concentrations of risperidone and its active metabolite. This may lead to loss of antipsychotic effect and relapse.
How serious is the interaction between Rifampin and Risperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of psychiatric control and consider increasing the risperidone dose. Reduce the dose again after rifampin is stopped.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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