Drug interactions
Rifampin + Trazodone
Severity: Moderate
Rifampin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin strongly induces CYP3A4, which is the main route of trazodone metabolism to its active metabolite. Trazodone concentrations can fall substantially, leading to loss of antidepressant or hypnotic effect.
What this interaction means in plain words
Rifampin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 increases trazodone clearance.
What to do
Monitor clinical response and increase the trazodone dose if needed. Reassess the dose after rifampin is stopped as induction wanes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Rifampin with Trazodone?
MediHelp rates the interaction as moderate. Rifampin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin strongly induces CYP3A4, which is the main route of trazodone metabolism to its active metabolite. Trazodone concentrations can fall substantially, leading to loss of antidepressant or hypnotic effect.
How serious is the interaction between Rifampin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the trazodone dose if needed. Reassess the dose after rifampin is stopped as induction wanes.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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