Drug interactions
Rifampin + Trimipramine
Severity: Moderate
Rifampin and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a potent inducer of CYP enzymes, including CYP3A4 and CYP2C19, and can lower tricyclic plasma concentrations. This may lead to reduced antidepressant effect or relapse.
What this interaction means in plain words
Rifampin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of hepatic and intestinal CYP-mediated metabolism of trimipramine by rifampin.
What to do
Monitor antidepressant response and trimipramine plasma levels if available, and increase the dose as needed. Reduce the dose again after rifampin is stopped, as induction wanes over weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rifampin and Trimipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Rifampin with Trimipramine?
MediHelp rates the interaction as moderate. Rifampin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a potent inducer of CYP enzymes, including CYP3A4 and CYP2C19, and can lower tricyclic plasma concentrations. This may lead to reduced antidepressant effect or relapse.
How serious is the interaction between Rifampin and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and trimipramine plasma levels if available, and increase the dose as needed. Reduce the dose again after rifampin is stopped, as induction wanes over weeks.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
