Drug interactions
Rifampin + Vortioxetine
Severity: Moderate
Rifampin and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a strong CYP inducer and substantially lowers vortioxetine exposure. This may reduce antidepressant efficacy and risk relapse.
What this interaction means in plain words
Rifampin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP enzymes (including CYP3A4 and others) by rifampin increases vortioxetine clearance.
What to do
Consider raising the vortioxetine dose if rifampin is used for more than about two weeks, not exceeding three times the original dose. Return to the original dose within two weeks of stopping rifampin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Rifampin with Vortioxetine?
MediHelp rates the interaction as moderate. Rifampin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a strong CYP inducer and substantially lowers vortioxetine exposure. This may reduce antidepressant efficacy and risk relapse.
How serious is the interaction between Rifampin and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider raising the vortioxetine dose if rifampin is used for more than about two weeks, not exceeding three times the original dose. Return to the original dose within two weeks of stopping rifampin.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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