Drug interactions
Rifapentine + Tamsulosin
Severity: Moderate
Rifapentine and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and can lower tamsulosin concentrations. Symptom control for benign prostatic hyperplasia may worsen during treatment.
What this interaction means in plain words
Rifapentine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifapentine belongs to Anti Bacterial; Tamsulosin belongs to Genitourinary.
Why it happens
Rifapentine induces CYP3A4 and other enzymes, increasing tamsulosin clearance.
What to do
Monitor urinary symptoms and consider increasing tamsulosin within the labeled range if response is lost. Reassess the dose after rifapentine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Rifapentine with Tamsulosin?
MediHelp rates the interaction as moderate. Rifapentine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP3A4 and can lower tamsulosin concentrations. Symptom control for benign prostatic hyperplasia may worsen during treatment.
How serious is the interaction between Rifapentine and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptoms and consider increasing tamsulosin within the labeled range if response is lost. Reassess the dose after rifapentine is stopped.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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