Drug interactions
Rifapentine + Tolazamide
Severity: Moderate
Rifapentine and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine may reduce tolazamide concentrations and cause worsening hyperglycemia. The effect is expected to be similar to, though somewhat weaker than, that of rifampin.
What this interaction means in plain words
Rifapentine and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifapentine belongs to Anti Bacterial; Tolazamide belongs to Endocrine.
Why it happens
Rifapentine induces hepatic metabolizing enzymes (CYP450 and others), increasing the clearance of tolazamide.
What to do
Check blood glucose frequently during rifapentine therapy and raise the tolazamide dose if control worsens. Reassess the dose when rifapentine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Rifapentine with Tolazamide?
MediHelp rates the interaction as moderate. Rifapentine and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine may reduce tolazamide concentrations and cause worsening hyperglycemia. The effect is expected to be similar to, though somewhat weaker than, that of rifampin.
How serious is the interaction between Rifapentine and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose frequently during rifapentine therapy and raise the tolazamide dose if control worsens. Reassess the dose when rifapentine is stopped.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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