Drug interactions
Rifapentine + Vinblastine
Severity: Moderate
Rifapentine and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is a CYP3A4 inducer and may lower vinblastine exposure. Loss of efficacy is a concern, especially during prolonged therapy.
What this interaction means in plain words
Rifapentine and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifapentine belongs to Anti Bacterial; Vinblastine belongs to Oncology.
Why it happens
Rifapentine induces CYP3A4, increasing vinblastine metabolic clearance.
What to do
Avoid the combination if alternatives exist. If antituberculous therapy is essential, monitor tumor response and coordinate with the oncologist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Rifapentine with Vinblastine?
MediHelp rates the interaction as moderate. Rifapentine and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine is a CYP3A4 inducer and may lower vinblastine exposure. Loss of efficacy is a concern, especially during prolonged therapy.
How serious is the interaction between Rifapentine and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if alternatives exist. If antituberculous therapy is essential, monitor tumor response and coordinate with the oncologist.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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