Drug interactions
Rifaximin + Stiripentol
Severity: Minor
Rifaximin and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits P-glycoprotein in vitro and may increase rifaximin absorption. Systemic exposure to rifaximin is normally very low, so clinical consequences are probably limited.
What this interaction means in plain words
Rifaximin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rifaximin belongs to Anti Bacterial; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits P-glycoprotein-mediated efflux of rifaximin.
What to do
No empirical dose change is needed. Monitor for rifaximin adverse effects, especially in severe liver disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rifaximin and Stiripentol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporine + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Rifaximin with Stiripentol?
MediHelp rates the interaction as minor. Rifaximin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits P-glycoprotein in vitro and may increase rifaximin absorption. Systemic exposure to rifaximin is normally very low, so clinical consequences are probably limited.
How serious is the interaction between Rifaximin and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for rifaximin adverse effects, especially in severe liver disease.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
