Drug interactions
Rilonacept + Siponimod
Severity: Moderate
Rilonacept and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siponimod lowers circulating lymphocytes, and rilonacept blocks interleukin-1 signalling. Used together they may add to immune suppression and raise the risk of serious infection.
What this interaction means in plain words
Rilonacept and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rilonacept belongs to Miscellaneous; Siponimod belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic immunosuppression through lymphocyte sequestration (S1P receptor modulation) and IL-1 blockade.
What to do
Monitor for signs of infection and check lymphocyte counts during combined use. Treat any active infection before starting either drug and reassess the need for the combination if infections occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Rilonacept
Frequently asked questions
Can I take Rilonacept with Siponimod?
MediHelp rates the interaction as moderate. Rilonacept and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siponimod lowers circulating lymphocytes, and rilonacept blocks interleukin-1 signalling. Used together they may add to immune suppression and raise the risk of serious infection.
How serious is the interaction between Rilonacept and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check lymphocyte counts during combined use. Treat any active infection before starting either drug and reassess the need for the combination if infections occur.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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