Drug interactions
Rilpivirine + Telavancin
Severity: Moderate
Rilpivirine and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so using them together may increase the risk of ventricular arrhythmias including torsades de pointes. The risk is higher in patients with electrolyte disturbances, structural heart disease or other QT-prolonging drugs.
What this interaction means in plain words
Rilpivirine and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rilpivirine belongs to Anti Virals; Telavancin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium before starting. Monitor the QTc during combined therapy and stop one agent if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Rilpivirine with Telavancin?
MediHelp rates the interaction as moderate. Rilpivirine and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, so using them together may increase the risk of ventricular arrhythmias including torsades de pointes. The risk is higher in patients with electrolyte disturbances, structural heart disease or other QT-prolonging drugs.
How serious is the interaction between Rilpivirine and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting. Monitor the QTc during combined therapy and stop one agent if the QTc becomes markedly prolonged.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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